Cell adhesion to polymeric materials: implications with respect to biocompatibility. [Gamma radiation, /sup 125/I]
Journal Article
·
· J. Biomed. Mater. Res.; (United States)
The adhesion of radio-labeled chick embryo muscle cells to the surfaces of radiation grafted hydrogels and other polymeric materials was measured in vitro. The degree of adhesion was determined by measuring the percentage of cells which remained adherent to the surfaces after 180 min of contact time (plating efficiency). Plating efficiency was found to vary between 2 and 94% depending on the nature of the surface. Preadsorption of albumin, ..gamma..-globulin or fibrinogen markedly affected subsequent adhesion of cells. Radiation grafted poly(2-hydroxyethyl methacrylate) and poly(N-vinyl-2-pyrrolidone) hydrogels on silicone rubber demonstrated exceptionally low adhesiveness in this assay. The potential for using this cell adhesion assay as a general screening test for biomaterials is discussed.
- Research Organization:
- Univ. of Washington, Seattle
- OSTI ID:
- 7214521
- Journal Information:
- J. Biomed. Mater. Res.; (United States), Journal Name: J. Biomed. Mater. Res.; (United States) Vol. 9; ISSN JBMRB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300* -- Cytology
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADHESION
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIRDS
CHICKENS
DAYS LIVING RADIOISOTOPES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EMBRYOS
FOWL
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IONIZING RADIATIONS
ISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
POLYMERS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
TRANSPLANTS
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADHESION
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIRDS
CHICKENS
DAYS LIVING RADIOISOTOPES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EMBRYOS
FOWL
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IONIZING RADIATIONS
ISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
POLYMERS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
TRANSPLANTS
VERTEBRATES