Modification of polyetherurethane for biomedical application by radiation induced grafting. II. Water sorption, surface properties, and protein adsorption of grafted films

Journal Article · Sun Jul 01 04:00:00 EDT 1984 · J. Biomed. Mater. Res.; (United States)

DOI:https://doi.org/10.1002/jbm.820180607· OSTI ID:5629795

Jansen, B; Ellinghorst, G

A series of polyetherurethane films grafted by means of gamma radiation with hydrophilic or reactive monomers (2-hydroxyethyl methacrylate, 2,3-epoxypropyl methacrylate, 2,3-dihydroxypropyl methacrylate, and acrylamide) and partially chemically modified were subjected to various physico-chemical investigation methods involving water sorption, contact angle, and protein adsorption measurements. From contact angle data the interfacial free energy gamma sw between grafted films and water was calculated. It was found that the water uptake of grafted films increases with grafting yield or, in the case of grafted and afterwards chemically modified films, with reaction yield; the diffusion coefficient of water in the modified films also increases with grafting yield. Contact angle studies revealed all grafted films to have surfaces more hydrophilic than the ungrafted trunk polymer. The degree of hydrophilicity--especially of HEMA-grafted films--strongly depends on grafting conditions. For some grafted samples with high surface hydrophilicity very low interfacial free energies approaching zero were measured. The study of the competitive adsorption of bovine serum albumin, gamma-globulin, and fibrinogen from a synthetic protein solution onto modified films showed that the adsorption of albumin increases markedly with increasing grafting yields, whereas the fibrinogen and gamma-globulin adsorption only slightly increases. A correlation between interfacial free energy and protein adsorption in the sense of the minimum interfacial free energy hypothesis was found only for samples with grafting yields below 5%. At higher grafting yields the increased surface area complicates the analysis.

• OSTI ID: 5629795
• Journal Information: J. Biomed. Mater. Res.; (United States), Journal Name: J. Biomed. Mater. Res.; (United States) Vol. 6; ISSN JBMRB
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600* -- Radiation Chemistry
550600 -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ADSORPTION
ALBUMINS
ANIMALS
BLOOD COAGULATION FACTORS
CATTLE
CHEMICAL RADIATION EFFECTS
CHEMISTRY
COAGULANTS
DOMESTIC ANIMALS
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
FIBRINOGEN
FILMS
GAMMA RADIATION
GLOBULINS
GLOBULINS-GAMMA
GRAFTS
HEMATOLOGIC AGENTS
HEMOSTATICS
HYDROGEN COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
OXYGEN COMPOUNDS
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYAMIDES
POLYMERS
POLYURETHANES
PROTEINS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RUMINANTS
SORPTION
SURFACE PROPERTIES
SYNTHETIC MATERIALS
TRANSPLANTS
VERTEBRATES
WATER