Mouse spleen lymphocyte bactericidal and peroxidase activites: enhancement by whole body X-irradiation
A 20,000 g pellet obtained from the homogenate of CD1 mouse spleen cells has measurable peroxidase and bactericidal activities. Whole body x-irradiation stimulates the in vitro peroxidative and bactericidal activities of the spleen cells. These cells do not phagocytize. However, addition of polystyrene latex particles to spleen cells from non- or x-irradiated mice, increases glucose oxidation. The extent of this stimulation (three- to fourfold) is less than that of PMN (six- to tenfold). Interaction between particles and lymphocyte surface may be the cause of this stimulation. The increased bactericidal activity due to x-ray is attribted mainly to an increase in the peroxidase activity of the lymphocytes. Surface (membrane) action rather that phagocytosis may be involved in the bactericidal process. The spleen lymphocyte peroxase is distinct from mylloproxidase in several resects.
- Research Organization:
- Tufts Univ., Boston
- OSTI ID:
- 7210920
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 152:2; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
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560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ENZYMES
EXTERNAL IRRADIATION
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MICE
MICROORGANISMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
PHAGOCYTOSIS
PORPHYRINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION