Transferrin function in zinc absorption and transport

Journal Article · Thu Apr 01 04:00:00 EST 1976 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-151-39305· OSTI ID:7210886

Evans, G W

Blood was drawn from the portal vein of rats immediately after the insertion of /sup 65/Zn into the duodenal lumen. Analysis of the plasma from the portal blood demonstrated that the major portion of absorbed /sup 65/Zn was bound to transferrin. When apotransferrin was incubated with /sup 65/Zn-labeled basolateral plasma membranes, 60% of the isotope was removed from the membrane. Zinc-free albumin prepared with histidine removed 25% of the /sup 65/Zn from labeled membranes and histidine had no effect. These results demonstrate that transferrin functions in the absorption and transport of zinc.

• Research Organization: Agricultural Research Service, Grand Forks, ND
• OSTI ID: 7210886
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 151:4; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLOBULINS
GLOBULINS-BETA
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOTOPES
MAMMALS
METALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SMALL INTESTINE
TISSUE DISTRIBUTION
TRANSFERRIN
UPTAKE
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES