Relation between four types of radiation damage and induced repair. [Escherichia coli; uv and gamma radiation]
Technical Report
·
OSTI ID:7208522
Four strains of Escherichia coli were exposed to uv and gamma radiation. Procedures are described for mutational studies, classification of revertants, inhibition of postirradiation DNA degradation and radioresistance. Comparisons were made of induction of the error-prone repair (epr) system with four mutagens; uv radiation, near uv radiation, gamma radiation, and DNA-protein crosslinks. An increase in the number of mutations was shown in every case. The observation that induction of mutagenesis, induction of inhibition of post-irradiation DNA degradation, and induction of radioresistance are closely parallel phenomena led to the investigation of the possibility that DNA-protein crosslinks which were known mutagens were also inducers of the epr system. The significance of the results is discussed. (HLW)
- Research Organization:
- Pennsylvania State Univ., University Park (USA). Dept. of Biochemistry
- OSTI ID:
- 7208522
- Report Number(s):
- TID-27772
- Country of Publication:
- United States
- Language:
- English
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Fri Jul 01 00:00:00 EDT 1977
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· Radiat. Res.; (United States)
·
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
CROSS-LINKING
DECOMPOSITION
DISEASES
DNA
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
INJURIES
IONIZING RADIATIONS
MICROORGANISMS
MUTAGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERIZATION
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
REPAIR
ULTRAVIOLET RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
CROSS-LINKING
DECOMPOSITION
DISEASES
DNA
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
GAMMA RADIATION
INJURIES
IONIZING RADIATIONS
MICROORGANISMS
MUTAGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERIZATION
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
REPAIR
ULTRAVIOLET RADIATION