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Pyrimidine dimer excision in exonuclease deficient mutants of Escherichia coli

Conference ·
OSTI ID:7208241

The rate of pyrimidine dimer excision has been measured in Escherichia coli strains deficient in exonuclease V, exonuclease VII, and the 5' ..-->.. 3' exonuclease of DNA polymerase I. The results suggest that a reduced level of the 5' ..-->.. 3' exonuclease of DNA polymerase I diminishes the rate of dimer excision and that an additional deficiency in exonuclease VII causes a significantly greater reduction in the cell's ability to remove dimers.

Research Organization:
Oak Ridge National Lab., Tenn. (USA); Albert Einstein Coll. of Medicine, Bronx, N.Y. (USA). Dept. of Molecular Biology
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
7208241
Report Number(s):
CONF-780226-5
Country of Publication:
United States
Language:
English