Pyrimidine dimer excision in exonuclease deficient mutants of Escherichia coli

Conference · Sun Jan 01 00:00:00 EST 1978

OSTI ID:7208241

Masker, W E; Chase, J W

The rate of pyrimidine dimer excision has been measured in Escherichia coli strains deficient in exonuclease V, exonuclease VII, and the 5' ..-->.. 3' exonuclease of DNA polymerase I. The results suggest that a reduced level of the 5' ..-->.. 3' exonuclease of DNA polymerase I diminishes the rate of dimer excision and that an additional deficiency in exonuclease VII causes a significantly greater reduction in the cell's ability to remove dimers.

• Research Organization: Oak Ridge National Lab., Tenn. (USA); Albert Einstein Coll. of Medicine, Bronx, N.Y. (USA). Dept. of Molecular Biology
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7208241
• Report Number(s): CONF-780226-5
• Resource Relation: Conference: Symposium on DNA repair mechanisms, Keystone, CO, USA, 19 Feb 1978
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ESCHERICHIA COLI
BIOCHEMICAL REACTION KINETICS
NUCLEASES
POLYMERASES
PYRIMIDINES
DIMERS
DNA
MUTANTS
AZINES
BACTERIA
ENZYMES
HETEROCYCLIC COMPOUNDS
KINETICS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOSPHOTRANSFERASES
REACTION KINETICS
TRANSFERASES
550200* - Biochemistry