Involvement of Escherichia coli DNA polymerase-I-associated 5' $Yields$ 3' exonuclease in excision-repair of uv-damaged DNA
Conference
·
OSTI ID:4126145
- ed.
From comparative studies between Escherichia coli PolA107 cells (lacking 5' $Yields$ 3' exonucleolytic activity associated with DNA polymerase I) and the isogenic wild-type strain, and between the purified DNA polymerase I preparations isolated from these strains, it can be concluded that the 5' $Yields$ 3' exonuclease is involved in excision of pyrimidine dimers in E. coli. Evidence is presented that the polA107 mutation is located on that part of the DNA polymerase I gene coding for the small fragment on which 5' $Yields$ 3' exonucleolytic activity is found. (auth)
- Research Organization:
- Leiden State Univ.
- NSA Number:
- NSA-33-012271
- OSTI ID:
- 4126145
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
*DNA-- BIOLOGICAL RADIATION EFFECTS
*ESCHERICHIA COLI-- BIOLOGICAL RADIATION EFFECTS
*NUCLEASES-- METABOLISM
*POLYMERASES-- METABOLISM
560131* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Microorganisms--Basic Studies
BIOLOGICAL REPAIR
CATALYSIS
MUTATIONS
N48110 --Life Sciences--Radiation Effects on Biochemicals--In-Vitro
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
ULTRAVIOLET RADIATION
*ESCHERICHIA COLI-- BIOLOGICAL RADIATION EFFECTS
*NUCLEASES-- METABOLISM
*POLYMERASES-- METABOLISM
560131* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Microorganisms--Basic Studies
BIOLOGICAL REPAIR
CATALYSIS
MUTATIONS
N48110 --Life Sciences--Radiation Effects on Biochemicals--In-Vitro
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
ULTRAVIOLET RADIATION