The time effect of chronic ethanol feeding on phospholipid fatty acids
- Univ. of California, Davis (United States)
The authors have previously shown that chronic ethanol feeding reduces arachidonic acid (AA) and other products of {delta}6 and {delta}5 desaturases in various tissues including muscle, the largest phospholipid (PL) pool. In this study they investigated the time-course effect of ethanol feeding on tissue fatty acid (FA) profiles. Five Yucatan micropigs were fed 89 kcal/kg body wt of diet containing ethanol and fat as 40 and 34% of energy, respectively. Five control pigs were pairfed corn starch instead of ethanol. Corn oil, 61% linoleic acid (LA), supplied most of dietary fat. PL fatty acids were quantitated by thin layer and gas chromatography. Below are FA profiles of control/ethanol groups by wt%. Underlined values differ p<0.05. In liver PL, ethanol resulted in increased LA but decreased palmitic acid, AA and docosahexaenoic acid (DHA) at 2 months. These changes remained constant for 12 months, whereas alpha-linolenic acid and DHA showed a progressive decline. For muscle, however, significant differences were not seen until 12 months. These results indicate time differences in ethanol effect on w6 and w3 FA composition, and that liver and muscle differ in their rates of response to ethanol. Their findings suggest that ethanol affects both desaturase activity and the precursor pool, and thus may alter membrane function.
- OSTI ID:
- 7206293
- Report Number(s):
- CONF-9204141-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 6:4; Conference: Federation of American Societies for Experimental Biology (FASEB) meeting, Anaheim, CA (United States), 5-9 Apr 1992; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBOXYLIC ACIDS
BIOSYNTHESIS
ETHANOL
BIOLOGICAL EFFECTS
CELL MEMBRANES
CHRONIC EXPOSURE
ENZYME ACTIVITY
GAS CHROMATOGRAPHY
LIVER
METABOLISM
MINIATURE SWINE
MUSCLES
OXYGENASES
PHOSPHOLIPIDS
THIN-LAYER CHROMATOGRAPHY
TIME DEPENDENCE
ALCOHOLS
ANIMALS
BODY
CELL CONSTITUENTS
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ENZYMES
ESTERS
GLANDS
HYDROXY COMPOUNDS
LIPIDS
MAMMALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
SEPARATION PROCESSES
SWINE
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology