Ethanol inhibits epileptiform activity and NMDA receptor-mediated synaptic transmission in rat amygdaloid slices
- Cheng-Kung Univ., Tainan (Taiwan)
The effect of ethanol on the epileptiform activity induced by Mg{sup ++}-free solution was studied in rat amygdalar slices using intracellular recording techniques. The spontaneous and evoked epileptiform discharges consisting of an initial burst followed by afterdischarges were observed 20-30 min after switching to Mg{sup ++}-free medium. Superfusion with ethanol reversibly reduced the duration of spontaneous and evoked bursting discharges in a concentration-dependent manner. Synaptic response mediated by N-methyl-D-aspartate (NMDA) receptor activation was isolated by application of a solution containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and either in Mg{sup ++}-free solution or in the presence of 50 {mu}M bicuculline. Application of ethanol reversibly suppressed the duration of NMDA receptor-mediated synaptic response. These results suggest that intoxicating concentrations of ethanol possess anticonvulsant activity through blocking the NMDA receptor-mediated synaptic excitation.
- OSTI ID:
- 7206281
- Report Number(s):
- CONF-9204141--
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 6:4; ISSN 0892-6638; ISSN FAJOE
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dithiothreitol elicits epileptiform activity in CA1 of the guinea pig hippocampal slice
MPTP-meditated hippocampal dopamine deprivation modulates synaptic transmission and activity-dependent synaptic plasticity
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ASPARTIC ACID
CARBOXYLIC ACIDS
DOSE-RESPONSE RELATIONSHIPS
ETHANOL
HYDROXY COMPOUNDS
INHIBITION
MAMMALS
MEMBRANE PROTEINS
METABOLISM
NERVE CELLS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RATS
RECEPTORS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES