Development of sampling and analytical methods for carcinogens, January 1--June 30, 1975. [Chemical carcinogens]
Activities pertaining to the development of sampling and analytical methods for chemical carcinogens are discussed. A compressed gas nebulizer has been designed to produce respirable, polydisperse aerosols of the aromatic amines on the Occupational Safety and Health Administration (OSHA) list of cancer-suspect agents. The aerosol passes through a sampling chamber which can be maintained at various environments from 25 to 40/sup 0/C and 0 to 100 percent relative humidity. A two-stage sampling tube incorporating a filter followed by a sorbent is proposed for collecting aerosols and associated vapors from air. High-speed liquid chromatography (HSLC) and gas chromatography have been explored for analyzing these aromatic amines. HSLC appears promising for 4,4'-methylene-bis(2-chloroaniline)(MOCA), benzidine, and 3,3'-dichlorobenzidine; preliminary solvent systems and detection limits are reported. Isomers of phthalaldehyde have been tested for nonspecific field detection of selected aromatic amines on the list. Detection limits are given using these reagents and fluorescamine for amines on various surfaces. Results of glove permeability tests indicate that natural latex and polyvinyl chloride are good materials for protecting skin from contact with MOCA and other aromatic amines. A chamber is described for testing respirator cartridges for breakthrough of the carcinogens. (auth)
- Research Organization:
- Los Alamos Scientific Lab., N.Mex. (USA)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 7193212
- Report Number(s):
- LA-6160-PR
- Country of Publication:
- United States
- Language:
- English
Similar Records
Development of sampling and analytical methods for carcinogens. Progress report, July 1--December 31, 1975
Interpretation and application of OSHA carcinogen standards for laboratory operations
Related Subjects
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AEROSOL GENERATORS
AEROSOLS
AIR POLLUTION MONITORS
AIR SAMPLERS
AMINES
CARCINOGENS
COLLOIDS
DISPERSIONS
LABORATORY EQUIPMENT
ORGANIC COMPOUNDS
PERFORMANCE TESTING
SAMPLERS
SAMPLING
SOLS
TESTING