Copper and zinc levels in serum from human patients with sarcomas

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(197601)37:1<356::AID-CNCR2820370146>3.0.CO;2-W· OSTI ID:7193114

Fisher, G L; Byers, V S; Shifrine, M; Levin, A S

Serum copper levels (SCL) and serum zinc levels (SZL) were evaluated in 19 patients with sarcomas, 12 of which were osteosarcomas at various stages. Patients with primary or metastatic osteosarcoma has elevated SCL, whereas amputated osteosarcoma patients who were clinically tumor-free had nearly normal SCL. Patients with primary osteosarcoma had elevated SZL, those with metastases had depressed zinc levels, and amputated patients who were clinically tumor-free had nearly normal SZL. Thus, the ratio of SCL:SZL in metastatic osteosarcoma patients is higher than in patients with primary osteosarcoma. SCL and SZL are compared to clinical histories for selected patients. Patients with the more advanced disease and poorest prognoses had the most elevated SCL and highest SCL:SZL ratios. It appears that the determination of SCL and SZL in osteosarcoma patients may be of value in prognosis and therapy evaluation; furthermore, the ratio of SCL:SZL may be useful in discriminating between patients with primary and metastatic osteosarcoma. (auth)

• Research Organization: Univ. of California, Davis
• OSTI ID: 7193114
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 37:1; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ABUNDANCE
COPPER
DIAGNOSIS
DISEASES
ELEMENTS
METALS
METASTASES
NEOPLASMS
OSTEOSARCOMAS
PATIENTS
SARCOMAS
SKELETAL DISEASES
THERAPY
TRANSITION ELEMENTS
ZINC