Serum copper and zinc levels in melanoma patients

Journal Article · Wed Apr 01 04:00:00 EST 1981 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19810401)47:7<1838::AID-CNCR2820470720>3.0.CO;2-6· OSTI ID:6551813

Fisher, G L ^[1]; Spitler, L E; McNeill, K L; Rosenblatt, L S

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1. Battelle Columbus Labs., OH

Serum copper levels (SCL) and serum zinc levels (SZL) were evaluated in malignant melanoma patients at various clinical stages. Copper levels were generally found to be elevated, reflecting the degree and extent of tumor activity. Zinc levels and, hence, SCL:SZL ratios did not reflect tumor activity. SCL appeared to prognosticate disease progression in that all patients whose values never declined below 150 ..mu..g/100 ml died during the course of the study. However, not all patients who died from tumor metastases displayed persistent elevations of SCL. Patients receiving BCG immunotherapy appeared to have higher SCL than untreated patients.

• OSTI ID: 6551813
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 47:7; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550900 -- Pathology
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD SERUM
COPPER
CORRELATIONS
DIAGNOSTIC USES
DISEASES
ELEMENTS
IMMUNOTHERAPY
MELANOMAS
METALS
NEOPLASMS
PATIENTS
QUANTITY RATIO
THERAPY
TRANSITION ELEMENTS
USES
ZINC