skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]

Abstract

This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub /sup 1///sub 2// = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of /sup 123/I-ICG (in dogs) will be compared to /sup 131/I-rose bengal and bromosulphalein labeled with iodine-125.

Authors:
; ; ;
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, N.Y. (USA)
OSTI Identifier:
7193112
Report Number(s):
BNL-20958; CONF-7509132-1
TRN: 76-015018
Resource Type:
Conference
Resource Relation:
Conference: Symposium on the biliary tract, Bordeaux, France, 4 Sep 1975
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BILIARY TRACT; PHYSIOLOGY; DYES; LABELLING; IODINE 123; BLOOD-PLASMA CLEARANCE; IODINE 125; IODINE 131; LIVER; PATIENTS; RADIATION DOSES; DOGS; METABOLISM; RADIOPHARMACEUTICALS; TRACER TECHNIQUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CLEARANCE; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DOSES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Lambrecht, R M, Ansari, A N, Wolf, A P, and Atkins, H L. Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]. United States: N. p., 1975. Web.
Lambrecht, R M, Ansari, A N, Wolf, A P, & Atkins, H L. Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]. United States.
Lambrecht, R M, Ansari, A N, Wolf, A P, and Atkins, H L. 1975. "Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]". United States. https://www.osti.gov/servlets/purl/7193112.
@article{osti_7193112,
title = {Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]},
author = {Lambrecht, R M and Ansari, A N and Wolf, A P and Atkins, H L},
abstractNote = {This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub /sup 1///sub 2// = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of /sup 123/I-ICG (in dogs) will be compared to /sup 131/I-rose bengal and bromosulphalein labeled with iodine-125.},
doi = {},
url = {https://www.osti.gov/biblio/7193112}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1975},
month = {1}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: