Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]

Conference · Wed Jan 01 00:00:00 EST 1975

OSTI ID:7193112

Lambrecht, R M; Ansari, A N; Wolf, A P; Atkins, H L

This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub /sup 1///sub 2// = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of /sup 123/I-ICG (in dogs) will be compared to /sup 131/I-rose bengal and bromosulphalein labeled with iodine-125.

• Research Organization: Brookhaven National Lab., Upton, N.Y. (USA)
• OSTI ID: 7193112
• Report Number(s): BNL-20958; CONF-7509132-1; TRN: 76-015018
• Resource Relation: Conference: Symposium on the biliary tract, Bordeaux, France, 4 Sep 1975
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BILIARY TRACT
PHYSIOLOGY
DYES
LABELLING
IODINE 123
BLOOD-PLASMA CLEARANCE
IODINE 125
IODINE 131
LIVER
PATIENTS
RADIATION DOSES
DOGS
METABOLISM
RADIOPHARMACEUTICALS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics