Simultaneous assessment of left ventricular wall motion and myocardial perfusion with technetium-99m-methoxy isobutyl isonitrile at stress and rest in patients with angina: Comparison with thallium-201 SPECT

Journal Article · Sun Apr 01 00:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:7192865

Villanueva-Meyer, J; Mena, I; Narahara, K A ^[1]

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1. UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance (USA)

The newly developed technetium-99m ({sup 99m}Tc) isonitriles can be used for the simultaneous evaluation of ventricular function and myocardial perfusion. We compared technetium-99m hexakis-2-methoxy isobutyl isonitrile (({sup 99m}Tc) MIBI) derived first-pass left ventricular wall motion at stress and rest with simultaneous myocardial perfusion defined by ({sup 99m}Tc)MIBI SPECT. These results were then compared with {sup 201}TI SPECT. We examined 28 patients with coronary artery disease; 25 had a previous myocardial infarction. We found concordance between segmental wall motion and myocardial perfusion imaging in defining normal, ischemic, and infarcted myocardium in 68% and 69% of segments using ({sup 99m}Tc)MIBI and {sup 201}TI respectively. The best agreement between wall motion and myocardial perfusion was seen in the inferior wall, while most of the discrepancies were found at the apex. Agreement between ({sup 99m}Tc)MIBI and {sup 201}TI SPECT myocardial perfusion was seen in 93% of segments. Technetium-99m-MIBI appears to be an ideal radiopharmaceutical for the simultaneous evaluation of ventricular function and myocardial perfusion during stress and at rest.

• OSTI ID: 7192865
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:4; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
HEART
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
EXERCISE
ISOMERIC NUCLEI
ISONITRILES
MAN
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BODY
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NUCLEI
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ORGANS
PRIMATES
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
TOMOGRAPHY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics