Progressive activation of paratrigeminal nucleus during entrance to hibernation

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:7191958

Kilduff, T S; Sharp, F R; Heller, H C ^[1]

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1. Stanford Univ., CA (USA) Univ. of California, San Francisco (USA) Veterans Administration Medical Center, San Francisco, CA (USA)

The paratrigeminal nucleus (Pa5) undergoes a progressive increase in its uptake of 2-({sup 14}C)deoxyglucose (2DG) relative to other brain structures during entrance to hibernation in the ground squirrel. This highly significant increase results in the Pa5 becoming the most highly labeled brain region during hibernation, even though it exhibits one of the lowest levels of 2DG uptake in the brain during the nonhibernating state. The progressive activation of the Pa5 observed during entrance is reversed during arousal from hibernation. These observations and the neuroanatomical projections of the Pa5 implicate this nucleus as playing a role in the entrance and maintenance of the hibernating state.

• OSTI ID: 7191958
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:1; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
GLUCOSE
HEXOSES
HIBERNATION
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
RODENTS
SACCHARIDES
SLEEP
SQUIRRELS
UPTAKE
VERTEBRATES