Radiosensitivity of ileum crypt cells in hibernating, arousing, and awake ground squirrels (Citellus tridecemlineatus)

Journal Article · Tue Jun 01 04:00:00 EDT 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574460· OSTI ID:7175834

Jaroslow, B N; Michael Fry, R J; Suhrbier, K M; Sallese, A R

Radiosensitivity of ileal crypt cells, to /sup 60/Co gamma radiation, was studied in ground squirrels (Citellus tridecemlineatus) during hibernation, arousal, and the euthermic state. Survival of ileal crypt cells, assayed by the microcolony technique from stained transverse sections of ileum, was greater in animals irradiated in hibernation or 1 hr after initiation of arousal from hibernation. Crypt survival returned to the level of irradiated nonhibernating controls in animals irradiated 3 to 7 hr after initiation of arousal. Over the exposure range of 1500 to 2400 R, the survival of crypt cells for euthermic controls gave a D/sub 0/ = 133 +- 12 R and for animals irradiated in hibernation it gave a D/sub 0/ = 487 +- 92 R. In animals irradiated 1 hr after initiation of arousal, when core temperature is within the range of euthermic controls, crypt survival was almost as high as in the hibernators. These results suggest that the increased resistance of ileal crypt cells in hibernating animals could be due to hypoxia, although not direct evidence for hypoxia in hibernation was established. The changes in mitotic index of ileal crypt cells during hibernation and arousal indicate an alteration in the distribution of cells in the phases of the cycle. This change in distribution may also have contributed to the increased radioresistance of hibernators.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 7175834
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 66:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COBALT 60
COBALT ISOTOPES
CRYPT CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HIBERNATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MITOTIC INDEX
NUCLEI
ODD-ODD NUCLEI
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
SQUIRRELS
TEMPERATURE DEPENDENCE
VERTEBRATES
YEARS LIVING RADIOISOTOPES