Leukotriene C4 elimination and metabolism in man

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Journal of Allergy and Clinical Immunology; (USA)

DOI:https://doi.org/10.1016/0091-6749(90)90214-O· OSTI ID:7191494

Maltby, N H; Taylor, G W; Ritter, J M; Moore, K; Fuller, R W; Dollery, C T ^[1]

---

1. Royal Postgraduate Medical School, London (England)

Three doses of radiolabeled leukotriene C4 (0.2 to 15 muCi) were infused into three subjects to investigate its metabolism and routes of elimination during 4 days. Between 12% and 20% of the infused dose was recovered in the urine within 24 hours, of which a substantial and relatively constant proportion (4.1% to 6.3% total dose) appeared as leukotriene E4 (LTE4), mainly in the first 4 hours. Polar omega-oxidation products, N-acetyl LTE4, and tritiated water were also present. Fecal elimination accounted for a further 30% to 40% of the infused dose. In the absence of altered metabolism or biliary excretion, urinary LTE4 may be a useful measure of whole body production of the cysteinyl leukotrienes.

• OSTI ID: 7191494
• Journal Information: Journal of Allergy and Clinical Immunology; (USA), Journal Name: Journal of Allergy and Clinical Immunology; (USA) Vol. 85; ISSN 0091-6749; ISSN JACIB
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
DOSE-RESPONSE RELATIONSHIPS
FECES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
MAN
MATERIALS
METABOLISM
PRIMATES
PROSTAGLANDINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
WASTES