Role of peripheral pooling in porcine Escherichia coli sepsis

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Circ. Shock; (United States)

OSTI ID:7190477

Teule, G J; von Lingen, A; Verwey von Vught, M A; Kester, A D; Mackaay, R C; Bezemer, P D; Heidenal, G A; Thijs, L G

In anesthesized pigs the effects of E. coli (2 X 10(8)/kg) on hemodynamics and red cell distribution were studied. After injection of 99m-Tc red cells (15 mCi), regional radioactivity was followed during 3 hours. Gated bloodpool studies were performed to measure end-diastolic volumes (EDV). Escherichia coli E. coli was infused in 14 pigs, while 7 animals served as controls. E. coli resulted in an early increase in pulmonary arterial pressure. Systemic arterial pressure decreased gradually, while cardiac output did not change significantly. The gated studies revealed that especially left ventricular end-diastolic volume (LVEDV) declined, to 50% of the basal value. Regional radioactivity did not change over lungs, liver and abdomen. Splenic activity declined markedly. Over the hindlimb a significant increase (29 +/- 8%) was observed. It is concluded that E. coli infusion in pigs induces a hemodynamic pattern similar to human sepsis. The decrease in LVEDV is probably related to peripheral pooling and a change in right ventricle (RV) performance.

• Research Organization: Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands
• OSTI ID: 7190477
• Journal Information: Circ. Shock; (United States), Vol. 12:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
INFECTIOUS DISEASES
PATHOGENESIS
TECHNETIUM 99
TRACER TECHNIQUES
BLOOD
ERYTHROCYTES
ESCHERICHIA COLI
INFECTIVITY
ISOMERIC NUCLEI
PERFUSED ORGANS
SWINE
ANIMALS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY
BODY FLUIDS
DISEASES
DOMESTIC ANIMALS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques
550701 - Microbiology- Tracer Techniques