Count-based method to calculate right ventricular volumes in children: In vitro and clinical validation

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6844109

Guiteras, P; deSouza, M E; Green, M; Ash, J M; Gilday, D; Olley, P

A rapid method for obtaining scintigraphic right ventricular volumes was developed and validated against cineangiography in 36 children, 10 with normal right ventricles (RV) and 26 with volume (VO) or pressure overload. Using a phantom, the authors validated the estimate of depth and the effect of different attenuation coefficients on volumes (V). End diastolic (EDV) and end systolic volumes (ESV) were calculated by dividing background corrected count rates by the count rate per millilitre of a reference blood sample. Attenuation corrected volume was given by V/e/sup -ud/, where u = linear attenuation coefficient and d = depth of the phantom or RV centre. Phantom volumes were accurately predicted (r = 0.99, p < .001) but only attenuation coefficients between 0.11/sup -1/cm. and 0.13/sup -1/ cm. yielded slopes close to 1. In-vivo data was therefore analyzed using u=0.11/sup -1/ with RV counts corrected with either RV or LV background. Closest agreement between scintigraphic and angiographic volumes was obtained using RV background (r = .91, p <.001, SEE 13 mls), although EDV's larger than 100 mls were substantially underestimated. The method was less accurate in VO particularly for ESV. The use of a larger attenuation coefficient (0.15/sup -1/ cm.) improved the estimate of EDV's, but reduced the accuracy of ESV's in children with either large or small ventricles and those with small body surface. The authors conclude that the optimum volume estimates require using an absorption coefficient of .11/sup -1/ for children with a body surface area less than .95m/sup 2/, and .15/sup -1/ in larger children.

• Research Organization: The Hospital for Sick Children, Toronto, Ontario
• OSTI ID: 6844109
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ACCURACY
AGE GROUPS
ATTENUATION
BIOMEDICAL RADIOGRAPHY
BLOOD COUNT
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHILDREN
COUNTING TECHNIQUES
DATA ANALYSIS
DEPTH
DIAGNOSTIC TECHNIQUES
DIMENSIONS
ENERGY
HEAT
IN VIVO
MEDICINE
MOCKUP
NUCLEAR MEDICINE
ORGANS
PHANTOMS
RADIOISOTOPE SCANNING
RADIOLOGY
SCINTISCANNING
STRUCTURAL MODELS
SURFACE AREA
SURFACE PROPERTIES
VOLUME