Role of peripheral pooling in porcine Escherichia coli sepsis
Journal Article
·
· Circ. Shock; (United States)
OSTI ID:7190477
In anesthesized pigs the effects of E. coli (2 X 10(8)/kg) on hemodynamics and red cell distribution were studied. After injection of 99m-Tc red cells (15 mCi), regional radioactivity was followed during 3 hours. Gated bloodpool studies were performed to measure end-diastolic volumes (EDV). Escherichia coli E. coli was infused in 14 pigs, while 7 animals served as controls. E. coli resulted in an early increase in pulmonary arterial pressure. Systemic arterial pressure decreased gradually, while cardiac output did not change significantly. The gated studies revealed that especially left ventricular end-diastolic volume (LVEDV) declined, to 50% of the basal value. Regional radioactivity did not change over lungs, liver and abdomen. Splenic activity declined markedly. Over the hindlimb a significant increase (29 +/- 8%) was observed. It is concluded that E. coli infusion in pigs induces a hemodynamic pattern similar to human sepsis. The decrease in LVEDV is probably related to peripheral pooling and a change in right ventricle (RV) performance.
- Research Organization:
- Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands
- OSTI ID:
- 7190477
- Journal Information:
- Circ. Shock; (United States), Journal Name: Circ. Shock; (United States) Vol. 12:2; ISSN CRSHA
- Country of Publication:
- United States
- Language:
- English
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Sun May 01 00:00:00 EDT 1988
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· Circulatory Shock; (USA)
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OSTI ID:6854694
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· J. Nucl. Med.; (United States)
·
OSTI ID:6844109
Related Subjects
550701 -- Microbiology-- Tracer Techniques
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DISEASES
DOMESTIC ANIMALS
ERYTHROCYTES
ESCHERICHIA COLI
HOURS LIVING RADIOISOTOPES
INFECTIOUS DISEASES
INFECTIVITY
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOGENESIS
PERFUSED ORGANS
RADIOISOTOPES
SWINE
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DISEASES
DOMESTIC ANIMALS
ERYTHROCYTES
ESCHERICHIA COLI
HOURS LIVING RADIOISOTOPES
INFECTIOUS DISEASES
INFECTIVITY
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOGENESIS
PERFUSED ORGANS
RADIOISOTOPES
SWINE
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES