Perinatal immunotoxicity of benzene toward mouse B cell development
Benzene is widely used by chemical industries and exposure to benzene has been shown experimentally to be immunotoxic in adult animals. The present study addressed whether exposure of fetuses in utero to benzene compromises the development of fetal B lymphopoiesis and whether B-lymphocyte development recovers postnatally. Pregnant BALB/C dams were given intraperitoneal injections of benzene (100 mg/kg, twice daily) from day 12.5 of gestation through day 19.5 of gestation. Phenotypic analysis revealed that fetal liver cell suspensions from embryos exposed in utero contained fewer pre-B cells and B cells than corresponding controls. Fetal liver cell cultures established from these embryos also produced fewer B cells. In contrast, pre-B cells were elevated in the livers of 8-day-old neonates that had been exposed to benzene in utero. Moreover, responsiveness to the B-cell mitogen, LPS, was significantly decreased in spleen cell cultures derived from these neonates. The results indicate that in utero exposure to high concentrations of benzene alters fetal B lymphopoiesis and may compromise immune responsiveness postnatally.
- Research Organization:
- West Virginia Univ., Morgantown, WV (USA)
- OSTI ID:
- 7190064
- Report Number(s):
- PB-90-199407/XAB
- Resource Relation:
- Other Information: Pub. in Jnl of the American College of Toxicology, Vol. 8, No. 5(1989)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BENZENE
TOXICITY
LYMPHOCYTES
CELL PROLIFERATION
BONE MARROW
CELL CULTURES
EMBRYOS
FETUSES
FLUORESCENCE
LIPOPOLYSACCHARIDES
LIVER
MICE
PHENOTYPE
PREGNANCY
SPLEEN
TERATOGENESIS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
GLANDS
HEMATOPOIETIC SYSTEM
HYDROCARBONS
LEUKOCYTES
LIPIDS
LUMINESCENCE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RODENTS
SACCHARIDES
SOMATIC CELLS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology