Induction of persistent hypersensitivity to lung tumorigenesis by in utero X-radiation in mice
Journal Article
·
· Environ. Mutagen.; (United States)
A single dose (36 rad) of X rays was given to mouse embryos and neonates that were then treated with urethane at 21 days of age. Although in utero X-radiation to mice was not tumorigenic, it significantly increased lung tumor susceptibility to a postnatally-given carcinogen, urethane. X-ray induction of persistent hypersensitivity to lung tumorigenesis was apparent at all stages during days 0 to 14 of gestation (except on day 6), but was not observed at late fetal and neonatal stages.
- Research Organization:
- Osaka Univ. Medical School, Japan
- OSTI ID:
- 7189396
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:1; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Induction of persistent hypersensitivity to lung tumorigenesis by in utero X-radiation in mice
Perinatal immunotoxicity of benzene toward mouse B cell development
Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· Environ. Mutagen.; (United States)
·
OSTI ID:6864194
Perinatal immunotoxicity of benzene toward mouse B cell development
Technical Report
·
Sat Dec 31 23:00:00 EST 1988
·
OSTI ID:7190064
Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene
Journal Article
·
Mon Nov 14 23:00:00 EST 2005
· Toxicology and Applied Pharmacology
·
OSTI ID:20783368
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBAMATES
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENESIS
DISEASES
ELECTROMAGNETIC RADIATION
EMBRYOS
IONIZING RADIATIONS
IRRADIATION
LABELLED COMPOUNDS
LUNGS
MAMMALS
MICE
NEONATES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RODENTS
URETHANE
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBAMATES
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENESIS
DISEASES
ELECTROMAGNETIC RADIATION
EMBRYOS
IONIZING RADIATIONS
IRRADIATION
LABELLED COMPOUNDS
LUNGS
MAMMALS
MICE
NEONATES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RODENTS
URETHANE
VERTEBRATES
X RADIATION