Provocation of skin graft rejection across murine class II differences by non--bone-marrow-derived cells

Journal Article · Sun Apr 01 04:00:00 EST 1984 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198404000-00016· OSTI ID:7189420

Stuart, P M; Beck-Maier, B; Melvold, R W

We have evaluated the relative contribution of bone-marrow-derived cells to skin allograft immunogenicity in mice differing only at class II major histocompatibility genes by using bone marrow radiation chimeras as donors. The mouse strains used were C57BL/6Kh (B6) and B6.C-H-2bm12 (bm12), which differ only at at A beta gene of the I region of the mouse H-2 complex. Our results demonstrated that skin from (B6----bm12) chimeras was accepted by bm12 recipients and rejected by B6 mice in a manner indistinguishable from that of normal bm12 skin. Likewise, naive bm12 mice rejected (bm12----B6) chimeric skin and normal B6 skin equally well, and B6 animals accepted both types of skin grafts. Our data argues that the donor cell-type leading to graft rejection across limited I region differences is not of bone marrow origin, and that these cells must--at least under certain circumstances--express class II antigens.

• Research Organization: Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois
• OSTI ID: 7189420
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 37:4; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
GRAFT-HOST REACTION
MAMMALS
MICE
MOSAICISM
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
TRANSPLANTS
VERTEBRATES