Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts
Journal Article
·
· J. Exp. Med.; (United States)
Lewis rats given total lymphoid irradiation (TLI) accepted bone marrow allografts from AgB-incompatible donors. The chimeras showed no clinical signs of graft-versus-host disease. Skin allografts from the marrow donor strain survived for more than 150 days on the chimeras. However, third-party skin grafts were rejected promptly. Although heart allografts survived more than 300 days in Lewis recipients given TLI and bone marrow allografts, detectable levels of chimerism were not required for permanent survival.
- Research Organization:
- Stanford Univ., CA
- OSTI ID:
- 5577663
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 147:3; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CARDIOVASCULAR SYSTEM
CHIMERAS
GRAFT-HOST REACTION
GRAFTS
HEART
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MOSAICISM
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SKIN
TISSUES
TRANSPLANTS
VERTEBRATES
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CARDIOVASCULAR SYSTEM
CHIMERAS
GRAFT-HOST REACTION
GRAFTS
HEART
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MOSAICISM
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SKIN
TISSUES
TRANSPLANTS
VERTEBRATES