Active immunization to luteinizing hormone releasing hormone to inhibit the induction of mammary tumors in the rat

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90288-3· OSTI ID:7189139

Ravdin, P M; Jordan, V C

Immunization of female rats with a bovine serum albumin-luteinizing hormone releasing hormone conjugate results in suppression of dimethylbenzanthracene mammary tumor incidence. Tumor incidence was 1.3, and 1.29 tumors per rat in bovine serum albumin alone (n = 10) and unimmunized (n = 18) control groups, but no tumors were found in the bovine serum albumin-luteinizing hormone releasing hormone conjugate immunized animals (n = 10). In a second experiment immunization with bovine serum albumin-luteinizing hormone releasing hormone conjugates reduced tumor incidence to 0.3 tumors per rat (n = 10) from the 1.2 tumors per animal seen in the control animals (n = 10) immunized with bovine serum albumin alone. Bovine serum albumin-luteinizing hormone immunization caused the production of anti-LHRH antibodies, an interruption of estrous cycles, lowered serum estradiol and progesterone levels, and atrophy of the ovaries and uteri. Immunization BSA-hormone conjugates is a novel anti-tumor strategy.

• Research Organization: Univ. of Wisconsin Cancer Center, Madison (USA)
• OSTI ID: 7189139
• Journal Information: Life Sci.; (United States), Vol. 43:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZANTHRACENE
CARCINOGENESIS
EXPERIMENTAL NEOPLASMS
IMMUNOSUPPRESSION
LH
BIOLOGICAL FUNCTIONS
MAMMARY GLANDS
ALBUMINS
RATS
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
FUNCTIONS
GLANDS
GONADOTROPINS
HORMONES
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology