Destruction of bovine ovarian follicles: effects on the pulsatile release of luteinizing hormone and prostaglandin F2 alpha-induced luteal regression

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Biol. Reprod.; (United States)

DOI:https://doi.org/10.1095/biolreprod36.3.523· OSTI ID:6169164

Hughes, T L; Villa-Godoy, A; Kesner, J S; Fogwell, R L

Destruction of ovarian follicles during diestrus prolongs the lifespan of corpora lutea in cows, but the site(s) of action is unclear. Thus, ovarian follicles were destroyed in 10 heifers (X-IRRAD) on Day 9 postestrus, while 10 additional heifers (SHAM) served as a control group. To investigate changes in luteotropic support resulting from destruction of ovarian follicles, pulses of luteinizing hormone (LH) were characterized on Days 8, 13, and 15 postestrus. To study the interaction between products from ovarian follicles and prostaglandin F2 alpha (PGF2 alpha) in luteolysis, changes in serum concentrations of progesterone were monitored after an injection of saline or PGF2 alpha on Day 14 postestrus. Frequency and amplitude of pulses of LH increased by Day 13 in X-IRRAD heifers. An increase of similar magnitude in amplitude but not frequency of pulses of LH occurred between Day 13 and Day 15 postestrus in SHAM heifers. Exogenous PGF2 alpha was significantly less efficacious in causing luteolysis in X-IRRAD animals. We suggest that increased luteotropic support may be involved in but is not the only cause for lengthening the lifespan of corpora lutea following destruction of ovarian follicles. Additionally, we suggest that regression of bovine corpora lutea involves a synergistic action between products from ovarian follicles and PGF2 alpha.

• Research Organization: Michigan State Univ., East Lansing
• OSTI ID: 6169164
• Journal Information: Biol. Reprod.; (United States), Journal Name: Biol. Reprod.; (United States) Vol. 36:3; ISSN BIREB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CATTLE
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
LH
MAMMALS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PROGESTERONE
PROSTAGLANDINS
RADIATION EFFECTS
RADIATIONS
RUMINANTS
SECRETION
STEROID HORMONES
STEROIDS
VERTEBRATES
X RADIATION