Infection in diabetic osteoarthropathy: use of indium-labeled leukocytes for diagnosis
Indium-111 labeled leukocyte imaging was compared with three-phase skeletal scintigraphy as a means of determining whether osteomyelitis was complicating diabetic osteoarthropathy. Three-phase scintigraphy demonstrated increased activity in both infected and noninfected osteopathic bone, with a sensitivity of 75% and a specificity of 56% for osteomyelitis. Leukocyte imaging had the same sensitivity but was most helpful for excluding infection (specificity, 89%) when three-phase imaging could not. Abnormal leukocyte localization was seen at the primary site of infection in all cases within 4 hours after injection. Disadvantages of leukocyte imaging included long preparation time, low count rates resulting in poor spatial resolution, and absence of bone landmarks, which made it difficult to differentiate soft tissue from bone infection.
- Research Organization:
- Temple Univ. Hospital, Philadelphia, PA
- OSTI ID:
- 7188705
- Journal Information:
- Radiology; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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BONE JOINTS
SCINTISCANNING
INDIUM 111
DIAGNOSTIC USES
LEUKOCYTES
OSTEOMYELITIS
DIAGNOSIS
DIABETES MELLITUS
PATIENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
METABOLIC DISEASES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETAL DISEASES
SKELETON
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics