Abnormalities in the cellular phase of blood fibrinolytic activity in systemic lupus erythematosus and in venous thromboembolism
Fibrinolytic activities of whole blood and plasma were determined by /sup 125/I-fibrin radiometric assay in 16 normal subjects, and in 11 patients with systemic lupus erythematosus (SLE), 14 with progressive systemic sclerosis (PSS), 23 with venous thromboembolic disease, and 20 patients awaiting elective surgery. Mean whole blood and plasma activities for patients with PSS, and for those awaiting elective surgery, were similar to normal values, as was the mean plasma activity in patients with SLE. However, mean whole blood activity in SLE was significantly decreased compared with normals (p less than 0.05), with mean plasma activity accounting for 44% of mean whole blood activity (compared with 17% in normal subjects), representing a 67% decrease in mean calculated cellular phase activity in SLE, when compared with normals. Since the numbers of cells (neutrophils, monocytes) possibly involved in cellular activity were not decreased, the findings suggest a functional defect in fibrinolytic activity of one or more blood cell types in SLE. An additional finding was the participation of the cellular phase as well as the well-known plasma phase of blood in the fibrinolytic response to thromboembolism.
- Research Organization:
- McGill Univ. Clinic, Montreal, Quebec
- OSTI ID:
- 7188678
- Journal Information:
- Thromb. Res.; (United States), Vol. 6
- Country of Publication:
- United States
- Language:
- English
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PATHOGENESIS
THROMBOSIS
BLOOD PLASMA
EMBOLI
FIBRIN
IODINE 125
LABELLED COMPOUNDS
MONOCYTES
NEUTROPHILS
PATIENTS
BACTERIAL DISEASES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
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BODY FLUIDS
CARDIOVASCULAR DISEASES
CHEMICAL REACTIONS
COAGULANTS
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
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DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATOLOGIC AGENTS
HEMOSTATICS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LEUKOCYTES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
PROTEOLYSIS
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SCLEROPROTEINS
SKIN DISEASES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics