Preparation and use of /sup 123/I-labeled highly indinated fibrinogen for imaging deep-vein thrombi. [Dogs]
A method for producing protein-iodination-grade /sup 123/I suitable for use with a compact biomedical cyclotron is reported. The preparation of highly iodinated fibrinogen (25 /sup 123/I atoms per molecule) is described, and its successful use as a thrombus-imaging agent in experimental animals is reported. This new agent clears from the blood faster than conventional radioiodinated fibrinogen and gives higher thrombus-to-blood activity ratios. Thus, the detection of deep-vein thrombi in areas of large blood pool is enhanced, and images can be obtained sooner after administration of the radiopharmaceutical. Induced 4-8-hr-old femoral-vein thrombi in dogs can be well visualized with a scintillation camera as early as 4 hr and as late as 15 hr after administration of 1 mCi of /sup 123/I-labeled highly iodinated fibrinogen.
- Research Organization:
- Mallinckrodt Inst. of Radiology, St. Louis
- OSTI ID:
- 7187516
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD COAGULATION FACTORS
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
FIBRINOGEN
GLOBULINS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLING
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SYNTHESIS
THROMBOSIS
VERTEBRATES