Monitoring pulmonary vascular permeability using radiolabeled transferrin
A simple, noninvasive technique for monitoring pulmonary vascular permeability in patients in critical care units is discussed. High vascular permeability is observed in patients with clinically defined adult respiratory distress syndrome (ARDS) but not in patients with hydrostatic pulmonary edema or in patients with minor pulmonary insults who are considered to be at risk of developing ARDS. The technique has been used in the field of therapeutics and pharmacology to test the effects of the putative antipermeability agents methylprednisolone and terbutaline sulfate. There appears to be a good correlation between the acute inhibitory effect of either drug on transferrin exudation and patient prognosis. Thus, a byproduct of such drug studies may be an index of survival in patients with established ARDS.
- Research Organization:
- Rotherham District General Hospital, South Yorkshire (England)
- OSTI ID:
- 7187295
- Journal Information:
- J. Thorac. Imaging.; (United States), Vol. 3:3, Issue 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD VESSELS
PERMEABILITY
RESPIRATORY SYSTEM DISEASES
DIAGNOSIS
TRANSFERRIN
LABELLING
ERYTHROCYTES
LABELLED COMPOUNDS
PATIENTS
SURVIVAL CURVES
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
DISEASES
GLOBULINS
GLOBULINS-BETA
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
METALLOPROTEINS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
550601* - Medicine- Unsealed Radionuclides in Diagnostics