Effect of DMSA loading on the renal handling of technetium-99m in rats
Journal Article
·
· Uremia Invest.; (United States)
OSTI ID:7187271
The renal handling of technetium-99m dimercaptosuccinic acid (99mTc DMSA) was studied in rats treated with high doses of nonradioactive DMSA to inhibit the renal uptake mechanism(s). A static scan was obtained 1 hour after the intravenous (iv) injection of 99mTc DMSA and the radioactivity in kidneys and bladder was calculated as a percentage of the injected amount. Total glomerular filtration rate (GFR) and effective renal plasma flow were also determined. Preloading with DMSA caused a fall in the renal accumulation of 99mTc DMSA together with a small increase in the amount excreted into the urinary bladder. Despite a stable GFR, the total amount of 99mTc DMSA handled by the kidneys (i.e., renal plus bladder activity) was reduced. These findings are compatible with the hypothesis that peritubular uptake and subsequent intracellular fixation are of importance in the renal accumulation of 99mTc DMSA. On the other hand, the radioactivity excreted into the urine probably stems from non-reabsorbed 99mTc DMSA initially filtered by the glomeruli.
- Research Organization:
- Erasmus Univ., Rotterdam, The Netherlands
- OSTI ID:
- 7187271
- Journal Information:
- Uremia Invest.; (United States), Journal Name: Uremia Invest.; (United States) Vol. 2; ISSN URIND
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Journal Article
·
Sat Jul 01 00:00:00 EDT 1989
· J. Nucl. Med.; (United States)
·
OSTI ID:5601713
99mTc DMSA renal uptake: influence of biochemical and physiologic factors
Journal Article
·
Mon Nov 30 23:00:00 EST 1981
· J. Nucl. Med.; (United States)
·
OSTI ID:5476144
The effect of maleate induced proximal tubular dysfunction on the renal handling of Tc-99m DMSA in the rat
Conference
·
Sat Dec 31 23:00:00 EST 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:6405348
Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLADDER
BODY
CLEARANCE
COUNTING TECHNIQUES
DITHIOLS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
REAGENTS
RENAL CLEARANCE
RODENTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
UPTAKE
URINARY TRACT
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLADDER
BODY
CLEARANCE
COUNTING TECHNIQUES
DITHIOLS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
REAGENTS
RENAL CLEARANCE
RODENTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
UPTAKE
URINARY TRACT
VERTEBRATES
YEARS LIVING RADIOISOTOPES