99mTc DMSA renal uptake: influence of biochemical and physiologic factors
Thirty-eight female Sprague-Dawley rats were studied to determine the effects of (a) tubular blockade and (b) commonly encountered changes in hydration and acid-base balance, on the urinary excretion and renal localization of 99mTc dimercaptosuccinic acid (DMSA). Ten additional rats were studied to quantitate the in vivo protein binding of 99mTc DMSA, and a final group of 12 animals was used to quantitate DMSA distribution in animals with diminished functional renal mass. Both osmotic diuresis and dehydration by water deprivation for 24 hr resulted in a plasma clearance of DMSA slower than in control animals. Acid-base imbalances significantly affected the renal accumulation of DMSA, and acidosis was associated with markedly increased background due to increased liver accumulation. The protein-bound portion of 99mTc DMSA in the plasma was high, reaching 89% within the first 5 min, and rising very slightly (n.s.) ith time. The unbound portion of DMSA had a plasma clearance slightly higher than the GFR. Ablation of large amounts of renal tissue, resulting in significant decreases in GFR, did not significantly affect the renal localization of DMSA in the intact portions of the kidneys. These data demonstrate that commonly encountered changes in acid-base balance and hydration will significantly alter the biologic distribution of 99mTc DMSA. These factors should be controlled when carrying out clinical studies.
- Research Organization:
- Albert Einstein College of Medicine, New York, New York
- OSTI ID:
- 5476144
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:12; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL BONDS
DEHYDRATION
DICARBOXYLIC ACIDS
DYNAMIC FUNCTION STUDIES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PH VALUE
PROTEINS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SUCCINIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES