Liver scarring induced by polychlorinated biphenyl administration to mice previously treated with diethylnitrosamine

Journal Article · Sat Nov 01 04:00:00 EST 1986 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-183-42406· OSTI ID:7187161

Gans, J H; Pintauro, S J

Exposure of mice for 8 weeks to drinking water containing diethylnitrosamine (DEN) was accompanied by alterations in hepatocyte structure and varying degrees of liver nonparenchymal cell (NPC) proliferation. Eighteen and a half weeks after cessation of DEN exposure, there was a 47% incidence of hepatocellular nodules. Centrilobular hepatocyte hypertrophy occurred consistently in mice given intraperitoneal injections of the polychlorinated biphenyl (PCB) mixture Aroclor 1254. PCB administration to mice previously treated with DEN was not accompanied by increases in gross liver nodule incidence above that induced by DEN, but many more developing microscopic nodules within the liver were observed in DEN-treated mice given Aroclor 1254 than in mice treated only with DEN. Aroclor 1254 administration over a 16-week period to mice previously treated with DEN was accompanied by an 83% incidence of severe distortion of liver structure resulting from nodule formation, uneven patterns of hepatocyte growth, and extensive deposition of scar tissue containing proliferating bile ducts. Morphological evidence of intestinal metaplasia was observed in proliferating bile duct-like structures during an early stage of liver adenofibrosis.

• Research Organization: Univ. of Vermont, Burlington
• OSTI ID: 7187161
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 183:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BODY
CELL PROLIFERATION
CHLORINATED AROMATIC HYDROCARBONS
DIGESTIVE SYSTEM
DISPERSIONS
DRINKING WATER
FIBROSIS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HYDROGEN COMPOUNDS
HYPERTROPHY
LIVER
LIVER CELLS
MAMMALS
MICE
MIXTURES
MORPHOLOGICAL CHANGES
NITROSO COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES
WATER