Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:6441821
The hepatic tumor-promoting activity of a commercial polychlorinated biphenyl mixture, Aroclor 1254 (AR 1254), with and without its intrinsic polychlorinated dibenzofuran (PCDF) impurities, was investigated. Male Sprague-Dawley noninbred albino rats were treated with 66 ..mu..g diethylnitrosamine (DENA)/ml drinking water for 5 weeks and subsequently given a control diet or a diet supplemented (100 ppM for 18 wk) with either AR 1254 or AR 1254 from which the PCDF moieties were removed (AR 1254-PCDF). Of those animals receiving DENA alone, 16% exhibited hepatocellular carcinomas. Of those rats treated with DENA followed by administration of AR 1254 or AR 1254-PCDF, 64 or 84%, respectively, developed hepatocellular carcinomas. Thus promotion with either AR 1254 or AR 1254-PCDF significantly (P < 0.05) increased the incidence of DENA-initiated hepatocellular carcinomas. Administration of AR 1254 or AR 1254-PCDF alone did not include hepatic tumors. Therefore, PCDF impurities were not necessary for the promoting activity of AR 1254.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 6441821
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 66:3; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Proliferative lesions of the glandular stomach and liver in F344 rats fed diets containing Aroclor 1254
Thermally induced formation of polychlorinated dibenzofurans from Aroclor 1254-contaminated mineral oil
Studies on polychlorinated biphenyls, with emphasis on the role of 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide in the metabolism of 2,2',5,5'-tetrachlorobiphenyl in the rat
Journal Article
·
Wed May 01 00:00:00 EDT 1985
· Environ. Health Perspect.; (United States)
·
OSTI ID:6177654
Thermally induced formation of polychlorinated dibenzofurans from Aroclor 1254-contaminated mineral oil
Journal Article
·
Tue Jan 31 23:00:00 EST 1989
· Environmental Health Perspectives; (USA)
·
OSTI ID:5645363
Studies on polychlorinated biphenyls, with emphasis on the role of 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide in the metabolism of 2,2',5,5'-tetrachlorobiphenyl in the rat
Thesis/Dissertation
·
Fri Dec 31 23:00:00 EST 1982
·
OSTI ID:5929636
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
GLANDS
HYDROGEN COMPOUNDS
LIVER
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PROMOTERS
RATS
RODENTS
TUMOR PROMOTERS
VERTEBRATES
WATER
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
GLANDS
HYDROGEN COMPOUNDS
LIVER
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PROMOTERS
RATS
RODENTS
TUMOR PROMOTERS
VERTEBRATES
WATER