Human hepatocytes metabolizing ethanol generate a non-polar chemotactic factor for human neutrophils
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
When human hepatocytes were incubated with low concentrations of ethanol they generate chemotactic activity for human neutrophils. Generation of chemotactic activity was dependent upon duration of incubation and concentration of ethanol used. Production of chemotactic activity by ethanol-treated hepatocytes was inhibited completely in the presence of the alcohol dehydrogenase inhibitor 4-methylpyrazole. Polymorphonuclear leukocytes (PMN) isolated from rats, in contrast, do not respond chemotactically to the factor released by homologous cells. Preliminary studies indicated that the chemotactic factor is non-polar in nature (perhaps related to leukotriene B/sub 4/). These results indicate that human hepatocytes, when exposed to ethanol, generate chemotactic factor(s) for human PMN. The occurrence of this phenomenon may explain, in part, the PMN infiltrates observed in human liver during the course of acute alcoholic hepatitis.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 7169793
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 137:2; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMAL CELLS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
ENZYMES
ETHANOL
ETIOLOGY
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INCUBATION
INFORMATION
INHIBITION
LEUKOCYTES
LIVER CELLS
MAMMALS
MATERIALS
METABOLIC DISEASES
NEUTROPHILS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRAZOLES
QUANTITY RATIO
RATS
RODENTS
SOMATIC CELLS
TIME DEPENDENCE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMAL CELLS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
ENZYMES
ETHANOL
ETIOLOGY
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INCUBATION
INFORMATION
INHIBITION
LEUKOCYTES
LIVER CELLS
MAMMALS
MATERIALS
METABOLIC DISEASES
NEUTROPHILS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRAZOLES
QUANTITY RATIO
RATS
RODENTS
SOMATIC CELLS
TIME DEPENDENCE
VERTEBRATES