Role of hypotension in decreasing cerebral blood flow in porcine endotoxemia

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:7164979

Miller, C F; Breslow, M J; Shapiro, R M; Traystman, R J ^[1]

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1. Johns Hopkins Medical Institutions, Baltimore, MD (USA)

The role of reduced arterial blood pressure (MAP) in decreasing cerebral blood flow (CBF) during endotoxemia was studied in pentobarbital-anesthetized pigs. Microspheres were used to measure regional CBF changes during MAP manipulations in animals with and without endotoxin. Endotoxin decreased MAP to 50 mmHg and decreased blood flow to the cortex and cerebellum without affecting cerebral cortical oxygen consumption (CMRo{sub 2}). Elevating MAP from 50 to 70 mmHg during endotoxemia with norepinephrine did not change cortical blood flow or CMRo{sub 2} but increased cerebellar blood flow. Brain stem blood flow was not affected by endotoxin or norepinephrine. When MAP was decreased to 50 mmHg by hemorrhage without endotoxin, no change in blood flow to cortex, cerebellum, or brain stem was observed from base-line levels. These results suggest that decreased MAP below a lower limit for cerebral autoregulation does not account for the decreased CBF observed after endotoxin.

• OSTI ID: 7164979
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:4; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

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