Effects of nonhypotensive endotoxemia in conscious rats: Role of prostaglandins

Journal Article · Tue Mar 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6867927

Burnier, M; Waeber, B; Aubert, J F; Nussberger, J; Brunner, H R ^[1]

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1. Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

A nonhypotensive dose of endotoxin was administered to normal conscious rats to evaluate the vascular and humoral effects of endotoxemia per se. Mean blood pressure and heart rate remained stable during the 45 min infusion of Escherichia coli endotoxin. However, a marked increase in plasma renin activity plasma epinephrine and plasma norepinephrine was observed during infusion in endotoxin-treated rats when compared with the vehicle-treated animals. In addition, the blood pressure response to exogenous norepinephrine was significantly reduced during nonhypotensive endotoxemia. Significant changes in regional blood flow distribution, as assessed by radiolabeled microspheres, were observed in endotoxemic rats; in particular a decrease in renal blood flow, and an increase in coronary blood flow were found. The role of prostaglandins in the vascular and humoral alterations induced by nonhypotensive endotoxemia was also examined. Pretreatment with indomethacin (5 mg) prevent the increase in plasma renin activity as well as plasma catecholamine levels. On the contrary, the decreased vascular reactivity and the reduction in renal blood flow observed during endotoxemia were not affected by prostaglandin synthesis inhibition. Thus significant vascular and humoral changes have been found during endotoxemia even in absence of hypotension. The humoral but not the vascular effects of endotoxemia were abolished when prostaglandin synthesis was inhibited.

• OSTI ID: 6867927
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
AMINES
ANIMALS
ANTIGENS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BACTERIA
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOTOXINS
ENZYMES
ESCHERICHIA COLI
EVEN-ODD NUCLEI
HYDROLASES
HYDROXY COMPOUNDS
HYPOTENSION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MATERIALS
MICROORGANISMS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NEUROREGULATORS
NONSPECIFIC PEPTIDASES
NORADRENALINE
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PHENOLS
PHYSIOLOGY
POLYPHENOLS
PROSTAGLANDINS
RADIOASSAY
RADIOISOTOPES
RATS
RENIN
RODENTS
SYMPATHOMIMETICS
TIN 113
TIN ISOTOPES
TOXIC MATERIALS
TOXINS
VERTEBRATES