Assessment of the behavioral toxicity of high-energy iron particles compared to other qualities of radiation
Technical Report
·
OSTI ID:7164853
Conditioned taste aversion was used to evaluate the behavioral toxicity of exposure to high-energy iron particles (56Fe, 600 MeV/amu) in comparison to that of gamma photons (60 Co), high-energy electrons, or fission neutrons. Exposure to high-energy iron particles (5-500 cGy) produced a dose-dependent taste aversion with a maximal effect achieved with a dose of 30 cGy. Gamma photons and electrons were the least-effective stimuli for producing a conditioned taste aversion, with a maximal aversion obtained only after exposure to 500 cGy, while the effectiveness of fission neutrons was intermediate to that of photons and iron particles, and a maximal aversion was obtained with a dose of 100 CGy. In the second experiment, rats with lesions of the area postrema were exposed to iron particles (3- cGY), but failed to acquire a taste aversion. The results indicate that (1) high-energy iron particles are more toxic than other qualities of radiation and (2) similar mechanisms mediate the behavioral toxicity of gamma photons and high-energy iron particles.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 7164853
- Report Number(s):
- AD-A-214329/5/XAB; AFRRI-SR--89-35
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BEAMS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
CONDITIONED REFLEXES
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
ENERGY RANGE
EVEN-EVEN NUCLEI
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
HADRONS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRON 56
IRON ISOTOPES
ISOTOPES
LEPTONS
MAMMALS
MASSLESS PARTICLES
MEV RANGE
MEV RANGE 100-1000
NEUTRONS
NUCLEI
NUCLEONS
ORGANS
PARTICLE BEAMS
PHOTONS
RADIATION EFFECTS
RADIATIONS
RATS
REFLEXES
RODENTS
SENSE ORGANS
STABLE ISOTOPES
STIMULI
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BEAMS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
CONDITIONED REFLEXES
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
ENERGY RANGE
EVEN-EVEN NUCLEI
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
HADRONS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRON 56
IRON ISOTOPES
ISOTOPES
LEPTONS
MAMMALS
MASSLESS PARTICLES
MEV RANGE
MEV RANGE 100-1000
NEUTRONS
NUCLEI
NUCLEONS
ORGANS
PARTICLE BEAMS
PHOTONS
RADIATION EFFECTS
RADIATIONS
RATS
REFLEXES
RODENTS
SENSE ORGANS
STABLE ISOTOPES
STIMULI
TOXICITY
VERTEBRATES