Nerve agents. Approaches to treatment/pretreatment. Annual report no. 2, 1 July-31 December 1983

Technical Report · Mon Jan 30 23:00:00 EST 1984

OSTI ID:7163048

Gray, A P; Platz, R D; Chang, T C; Leverone, T R; Ferrick, D A

The ultimate objective of this work is to develop potential antidotes for the therapeutic and/or prophylactic treatment of nerve agent intoxication. Particular concern is with soman intoxication where aging of the inhibited enzyme acetylcholinesterase (AChE) is a serious complication factor. Primary emphasis continued to be placed on the investigation of compounds able to inhibit the synthesis of acetylcholine (ACh). A secondary area of interest the investigation of the possibility of combining the ability to slow the rate of aging with the ability to reactivate soman-inhibited AChE. With respect to inhibitors of ACh synthesis, we have continued to investigate the effects of hemicholinium-3 (HC-3), an inhibitor of choline transport and naphthylvinylpyridine hydroxyethyl bromide (B-111), an inhibitor of choline acetyltransferase (CAT), after intracerebroventricular injection in the rat. The ability of HC-3 to prevent the rise in brain ACh levels induced by soman has been confirmed. The ability of B-111 to inhibit brain CAT activity both in soman-treated and untreated rats has been confirmed, although results have been somewhat inconsistent.

• Research Organization: Dynamac Corp., Rockville, MD (USA)
• OSTI ID: 7163048
• Report Number(s): AD-A-171372/6/XAB
• Country of Publication: United States
• Language: English

Related Subjects

99 GENERAL AND MISCELLANEOUS
990100* -- Management
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL WARFARE AGENTS
BODY
BRAIN
CARBOXYLESTERASES
CENTRAL NERVOUS SYSTEM
CHOLINESTERASE
DRUGS
ENZYMES
ESTERASES
ESTERS
HYDROLASES
MAMMALS
MEDICINE
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PREVENTIVE MEDICINE
QUATERNARY COMPOUNDS
RATS
RODENTS
THERAPY
TRANSFERASES
VERTEBRATES
WEAPONS