The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21. 1 and is close to the gene for hereditary breast-ovarian cancer

Journal Article · Mon Nov 01 04:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1487· OSTI ID:7160085

Tonin, P; Vivier, A; Morgan, K; Narod, S; Pollack, M ^[1]; Ehrenborg, E; Zazzi, H; Luthman, H; Larsson, C ^[2]; Lenoir, G ^[3]

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1. McGill Univ., Montreal (Canada)
2. Karolinska Hospital, Stockholm (Sweden)
3. International Agency for Research on Cancer, Lyon (France); and others

The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. It has been mapped by in situ hybridization to chromosome region 17q12-q21.1. The authors have developed a CA-repeat polymorphism from a cosmid clone containing IGFBP4. By linkage analysis, IGFBP4 maps to the chromosome 17q interval THRA1-D17S579. This interval also contains the gene for hereditary breast-ovarian cancer, BRCA1. Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1. 18 refs., 3 figs., 1 tab.

• OSTI ID: 7160085
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 18:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BODY
CHROMOSOMES
DISEASES
FEMALE GENITALS
GENETIC MAPPING
GLANDS
GONADS
GROWTH FACTORS
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
MAMMARY GLANDS
MAPPING
MITOGENS
MODULATION
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PROTEINS