THRA1 and D17S183 flank an interval of <4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21

Journal Article · Wed Mar 31 23:00:00 EST 1993 · American Journal of Human Genetics; (United States)

OSTI ID:6083140

Bowcock, A M; Osborne-Lawrence, S ^[1]; Anderson, L A; Friedman, L S; Rowell, S E; Hall, J M; King, M C ^[2]; Black, D M; Solomon, E ^[3]

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1. Univ. of Texas Southwestern Medical Center, Dallas (United States)
2. Univ. of California, Berkeley (United States)
3. Imperial Cancer Research Fund, London (United Kingdom)

In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. The THRA1 polymorphism is a dinucleotide repeat with 10 alleles and heterozygosity .79. Gene mapping in extended families with inherited, early-onset breast and ovarian cancer indicates that BRCA1 is distal to THRA1 and proximal to D17S183 (SCG43), an interval of <4 cM. This locale excludes HER2, THRA1, WNT3, HOX2, NGFR, PHB, COLIA1, NME1, and NME2 as candidates for BRCA1 but does not exclude RARA or EDH17B. Resolving the remaining recombination events in these families by new polymorphisms in the THRA1-D17S183 interval will facilitate positional cloning of the breast-ovarian cancer gene on chromosome 17q12-q21. 16 refs., 3 figs., 1 tab.

• OSTI ID: 6083140
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 52:4; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BODY
CHROMOSOMES
DISEASES
FEMALE GENITALS
GENES
GENETIC MAPPING
GLANDS
GONADS
HORMONES
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
MAMMARY GLANDS
MAPPING
MEMBRANE PROTEINS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PEPTIDE HORMONES
PROTEINS
RECEPTORS
RFLPS
THYROID HORMONES