Modulation of the clastogenic activity of ionizing radiation and bleomycin by the aminothiol WR-1065

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850220408· OSTI ID:7159451

Littlefield, L G ^[1]; Hoffmann, G R ^[2]

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1. Oak Ridge Institute for Science and Education, TN (United States)
2. College of the Holy Cross, Worcester, MA (United States)

WR-1065 (2-[(aminopropyl)amino]ethanethiol) reduces the induction by ionizing radiation of genetic damage, including DNA single- and double-strand breaks, chromosomal aberrations, micronuclei, and hprt mutations in mammalian cells. The effectiveness of WR-1065 as a radioprotector is apparently enhanced by its tendency, a a cationic thiol, to concentrate near DNA. The authors have studied the modulation by WR-1065 of the induction of chromosome aberrations and micronuclei in G[sub 0] human lymphocytes by ionizing radiation and by the radiomimetic chemical bleomycin.

• DOE Contract Number: AC05-76OR00033
• OSTI ID: 7159451
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Journal Name: Environmental and Molecular Mutagenesis; (United States) Vol. 22:4; ISSN 0893-6692; ISSN EMMUEG
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
BARYONS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA REPAIR
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
HADRONS
IONIZING RADIATIONS
NEUTRONS
NUCLEONS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
REPAIR
STRAND BREAKS
THIOLS
X RADIATION