Molecular epidemiology of coal worker's pneumoconiosis: Application to risk assessment of oxidant and monokine generation by mineral dusts
Journal Article
·
· Experimental Lung Research; (USA)
- Univ. of Limburg, Maastricht (Netherlands)
It is generally accepted that fibrotic lung diseases are mediated by macrophage-derived cytokines and growth factors. Basic research continues to find new factors involved in these disease processes to incorporate into new hypotheses. Two hypotheses implicitly generated by recent findings were tested in an epidemiologic approach among workers in coal mines. This approach is described as molecular epidemiology and is exemplified by two studies focused on different mechanistic aspects of coal workers' pneumoconiosis (CWP): antioxidants in red blood cells of miners with CWP and generation of tumor necrosis factor (TNF) by blood monocytes of miners with CWP. Most findings in the antioxidant study may merely be reflections of pulmonary inflammatory processes. Some data in the TNF study indicate, however, that TNF release is a risk factor for the development of lung fibrosis after prolonged exposure to coal mine dust.
- OSTI ID:
- 7158241
- Journal Information:
- Experimental Lung Research; (USA), Journal Name: Experimental Lung Research; (USA) Vol. 16:1; ISSN 0190-2148; ISSN EXLRD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
016000* -- Coal
Lignite
& Peat-- Health & Safety
ANIMAL CELLS
ANTIOXIDANTS
BELGIUM
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COAL MINERS
COAL MINING
CONNECTIVE TISSUE CELLS
DISEASES
DUSTS
EPIDEMIOLOGY
ERYTHROCYTES
EUROPE
FIBROSIS
GROWTH FACTORS
HAZARDS
HEALTH HAZARDS
LUNGS
LYMPHOKINES
MACROPHAGES
MATERIALS
MINERS
MINING
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERSONNEL
PHAGOCYTES
PNEUMOCONIOSES
PROTEINS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
SOMATIC CELLS
SYNTHESIS
WESTERN EUROPE
016000* -- Coal
Lignite
& Peat-- Health & Safety
ANIMAL CELLS
ANTIOXIDANTS
BELGIUM
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COAL MINERS
COAL MINING
CONNECTIVE TISSUE CELLS
DISEASES
DUSTS
EPIDEMIOLOGY
ERYTHROCYTES
EUROPE
FIBROSIS
GROWTH FACTORS
HAZARDS
HEALTH HAZARDS
LUNGS
LYMPHOKINES
MACROPHAGES
MATERIALS
MINERS
MINING
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERSONNEL
PHAGOCYTES
PNEUMOCONIOSES
PROTEINS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
SOMATIC CELLS
SYNTHESIS
WESTERN EUROPE