Increased delivery of gallium-67 to tumors using serum-stable liposomes

Journal Article · Thu Mar 31 23:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:7154098

Ogihara-Umeda, I; Kojima, S

Gallium-67 chelated to nitrilotriacetic acid was encapsulated in liposomes composed of various phospholipids, and /sup 67/Ga delivery potential to the tumor after intravenous injection of these liposomes was examined. Tumor uptake of the liposomes themselves and their stability in the serum were also studied. It was found that liposomes composed of distearoylphosphatidylcholine, diarachidoylphosphatidylcholine, or sphingomyelin with cholesterol (molar ratio of phospholipid:cholesterol, 2:1) could be taken by the tumor effectively and could deliver large amounts of /sup 67/Ga to the tumor. They could also give high /sup 67/Ga accumulation ratios (tumor to the other tissues). The study of liposomal stability in the serum suggested that the marked /sup 67/Ga accumulation in the tumor resulted from the serum stability of the liposomal bilayer, i.e., the stable liposomes in the blood circulation could reach the tumor in large quantities after i.v. injection. These observations indicate that liposomes with an appropriate lipid composition may be an excellent tool to accumulate /sup 67/Ga in tumors.

• Research Organization: Teikyo Univ., Kanagawa (Japan)
• OSTI ID: 7154098
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
CELL CONSTITUENTS
CHOLESTEROL
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
GALLIUM 67
GALLIUM ISOTOPES
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPES
LIPIDS
LIPOSOMES
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
PHOSPHOLIPIDS
RADIOISOTOPES
RODENTS
SPHINGOMYELINS
STEROIDS
STEROLS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES