Differential uptake of gallium-67-labeled liposomes between tumors and inflammatory lesions in rats

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · J. Nucl. Med.; (United States)

OSTI ID:5124923

Ogihara, I; Kojima, S; Jay, M

The differential gallium-67 (/sup 67/Ga) accumulation in tumors and inflammatory lesions in rats after i.v. injection of liposome encapsulated /sup 67/Ga ((/sup 67/Ga)liposomes) was studied. The /sup 67/Ga accumulation in the tumor was much greater than that in the granulation tissue regardless of the surface charge of liposomes; however, the difference between the two tissues was the greatest when using positive charged liposomes. Gallium-67 delivery to tumors by liposomes was greater than that to granulation tissue in all stages of growth. After i.v. injection, the accumulation of /sup 67/Ga in the tumor reached a maximum at 12 hr, whereas in the granulation tissue it was delayed to 24 hr postinjection. In the study of tissue distribution of /sup 67/Ga in rats bearing both tumor and granulation tissue, positively charged liposomes preferentially delivered /sup 67/Ga to the tumor than to the granulation tissue. These results suggest that (/sup 67/Ga)liposomes are able to discriminate between the tumor and the inflammatory lesion.

• Research Organization: Teikyo Univ., Kanagawa, Japan
• OSTI ID: 5124923
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
CARRIERS
CELL CONSTITUENTS
CHEMICAL STATE
COLLAGEN
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
INFLAMMATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIPOSOMES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
PATHOLOGICAL CHANGES
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SCLEROPROTEINS
SYMPTOMS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES