Effect of anticholinesterase agents on airway epithelial function. Annual report, 15 July 1888-14 August 1989
Irreversible anticholinesterase compounds have potential serious health effects when employed as chemical warfare agents. Intoxication with these agents will cause an accumulation of acetylcholine at nerve muscle and nerve-gland junctions. Because tracheal glands have rich cholinergic innervation, we hypothesized that exposure to anticholinesterase agents, such as soman, would stimulate glandular secretion. This would cause pathological changes in the important lung defense mechanism of mucociliary clearance. Initial work on this contract revealed a dose-related increase in mucociliary transport in the ferret in response to soman. This effect could be inhibited by atropine but not by pralidoxime. The investigation described in this report relates to the effects of soman and its antidotes on glycoconjugate secretion of ferret trachea in vitro.
- Research Organization:
- Rochester Univ., NY (USA)
- OSTI ID:
- 7148500
- Report Number(s):
- AD-A-214475/6/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AUTONOMIC NERVOUS SYSTEM AGENTS
HEALTH HAZARDS
CHEMICAL WARFARE AGENTS
EPITHELIUM
RESPONSE FUNCTIONS
RESPIRATORY SYSTEM
ACETYLCHOLINE
ATROPINE
GLANDS
IRREVERSIBLE PROCESSES
LUNGS
PATHOLOGY
PROGRESS REPORT
SECRETION
TRACHEA
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
ANIMAL TISSUES
BODY
DOCUMENT TYPES
DRUGS
ESTERS
FUNCTIONS
HAZARDS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
TISSUES
WEAPONS
450600* - Military Technology
Weaponry
& National Defense- Chemical & Biological- (1990)