Comparison of the tumorigenic response of SENCAR and C57BL/6 mice to benzo(a)pyrene and the interexperimental variability over a three-year period
SENCAR and C57BL/6 mice were compared for their ability to produce tumors after benzo(a) pyrene (B(a)P) initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion. SENCAR ice initiated with 101 ..mu..g/mouse B(a)P and promoted with TPA produced large numbers of papillomas, whereas C57BL/6 mice produced none after 26 weeks of promotion. Continued treatment of the B(a)P-initiated C57BL/6 mice with TPA up to 52 weeks did not induce any papillomas nor did higher doses of B(a)P. Application of increased doses of TPA to B(a)P-initiated C57BL/6 mice for 50 weeks produced few papillomas. Substantial papilloma formation in C57BL/6 mice was observed after weekly treatment with B(a)P, with maximal production occurring at weeks 39 to 41 of treatment. In contrast, SENCAR mice treated according to the same protocol produced an equivalent response with maximal papilloma formation occurring 12 to 13 weeks earlier. Therefore, C57BL/6 mice exposed to B(a)P are capable of producing papillomas under certain experimental conditions. The inter-experimental variability of B(a)P-induced papilloma formation after 30 weeks of TPA promotion was examined in SENCAR mice over a 37-month period. Low statistical variation was observed in papilloma multiplicity, papilloma incidence, or papilloma latency. The numbers of papillomas per mouse did not follow a Poisson distribution. These data can serve as a reference source for future comparisons of mouse skin tumor initiation results between SENCAR and other strains or stocks of mice and with other chemicals.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC
- OSTI ID:
- 7145230
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 68; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
CARCINOGENESIS
CARCINOGENS
CONDENSED AROMATICS
DISEASES
ESTERS
HYDROCARBONS
MAMMALS
MATHEMATICS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PHORBOL ESTERS
PROMOTERS
RODENTS
SKIN
SPECIES DIVERSITY
STATISTICS
TUMOR PROMOTERS
VERTEBRATES