Effects of x-irradiation on steroid biotransformations by testicular tissue. Final report, May 1, 1966--July 31, 1976. [Rats]
A number of parameters of testicular and body function were investigated after various dosages of x-irradiation to ascertain: what relationship they have to the radiation syndrome and testicular repression and regeneration of the rat; and how sensitive these parameters are to radiation. Changes in androgen synthesis were not well correlated with either body or gonad weights, hematocrit values or testicular histology. Lipid peroxidation, catalase activity, metabolism of testosterone, prostaglandins, cyclic nucleotides and serotonin metabolism were all related to the direct effects of radiation on the male gonad. Indirect effects on the testis appear to be mediated by serotonin and the pineal gland. The pineal gland appeared to be responsible for variations in androgen synthesis and radiosensitivity of the testis through its secretory products-melatonin and arginine vasopressin. These compounds have the capacity of inducing endocrine rhythms by affecting: the hypothalamus-pituitary axis; the liver; and/or the gonad directly.
- Research Organization:
- Utah State Univ., Logan (USA). Dept. of Biology
- DOE Contract Number:
- EY-76-S-02-1602
- OSTI ID:
- 7144984
- Report Number(s):
- COO-1602-60
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANDROGENS
ANDROSTANES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CATALASE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
GLANDS
GONADS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
HORMONES
HYDROXY COMPOUNDS
INDOLES
IONIZING RADIATIONS
KETONES
LIPIDS
MALE GENITALS
MAMMALS
METABOLISM
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PINEAL GLAND
PROSTAGLANDINS
PYRROLES
RADIATION EFFECTS
RADIATION SYNDROME
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SEROTONIN
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
SYNTHESIS
TESTES
TESTOSTERONE
TRYPTAMINES
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANDROGENS
ANDROSTANES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CATALASE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
GLANDS
GONADS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
HORMONES
HYDROXY COMPOUNDS
INDOLES
IONIZING RADIATIONS
KETONES
LIPIDS
MALE GENITALS
MAMMALS
METABOLISM
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PINEAL GLAND
PROSTAGLANDINS
PYRROLES
RADIATION EFFECTS
RADIATION SYNDROME
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SEROTONIN
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
SYNTHESIS
TESTES
TESTOSTERONE
TRYPTAMINES
VERTEBRATES
X RADIATION