Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors
Journal Article
·
· Mol. Cell. Biol.; (United States)
By using Southern blot analysis, the authors found that in two cases of human glioblastoma multiforme, cells carried amplified c-erbB genes which bore short deletion mutations within the ligand-binding domain of the epidermal growth factor (EGF) receptor. The products of these mutated c-erB genes were about 30 kilodalton (kDa) smaller than the normal 170-kDa EGF receptor, and the tumor cell membrane fractions containing the 140-kDa abnormal EGF receptor showed a significant elevation of tyrosine kinase activity without its ligand. In view of the similarity to the activated viral and cellular erbB genes in the avian system, these mutated and overexpressed EGF receptors might play a role in the onset or development of human glioblastoma cells.
- Research Organization:
- Dept. of Genetics, Institute of Medical Science, The Univ. of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108 (JP)
- OSTI ID:
- 7143983
- Journal Information:
- Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 8:4; ISSN MCEBD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMAL TISSUES
BODY
BRAIN
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CONTROL
DISEASES
ENZYME ACTIVITY
ENZYMES
EPIDERMIS
EPITHELIUM
GENE AMPLIFICATION
GENES
GENETIC CONTROL
GLIOMAS
GROWTH FACTORS
HISTOLOGY
HUMAN POPULATIONS
HYDROXY ACIDS
LIGANDS
MEMBRANE PROTEINS
MEMBRANES
MICROORGANISMS
MITOGENS
MUTATIONS
NEOPLASMS
NERVOUS SYSTEM
ONCOGENES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARASITES
PEST CONTROL
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
POPULATIONS
PROTEINS
RECEPTORS
SKIN
SOMATIC CELLS
TISSUES
TRANSFERASES
TUMOR CELLS
TYROSINE
VIRUSES
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMAL TISSUES
BODY
BRAIN
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CONTROL
DISEASES
ENZYME ACTIVITY
ENZYMES
EPIDERMIS
EPITHELIUM
GENE AMPLIFICATION
GENES
GENETIC CONTROL
GLIOMAS
GROWTH FACTORS
HISTOLOGY
HUMAN POPULATIONS
HYDROXY ACIDS
LIGANDS
MEMBRANE PROTEINS
MEMBRANES
MICROORGANISMS
MITOGENS
MUTATIONS
NEOPLASMS
NERVOUS SYSTEM
ONCOGENES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARASITES
PEST CONTROL
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
POPULATIONS
PROTEINS
RECEPTORS
SKIN
SOMATIC CELLS
TISSUES
TRANSFERASES
TUMOR CELLS
TYROSINE
VIRUSES