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Dynamic measurement of regional ventilation and perfusion of the lung with /sup 133/Xe

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:7142905
; ;
A method for measuring regional distribution of ventilation and perfusion with Xe-133 during tidal breathing was developed with normal subjects, and compared with current breath-holding techniques in patients and in animals. Normal values for a ventilation index during washin, a perfusion index, and a washout slope index were determined in both supine and upright normal subjects. Comparisons of tidal-breathing and breath-holding measurements in patients with localized bullous disease of the lung showed roughly equal values for perfusion index by the two methods, but the tidal-breathing method was more sensitive to abnormalities in ventilation index. During occlusion of branches of the pulmonary artery in animals, the tidal-breathing and breath-holding methods were again comparable in the measurement of perfusion indices, but the tidal-breathing method provided a more sensitive assessment of ventilatory changes due to partial bronchial occlusion in animals. This technique appears superior to standard methods and is well suited to dynamic measurement of regional ventilation and perfusion in a number of experimental and clinical circumstances.
Research Organization:
Univ. of Texas, Dallas
OSTI ID:
7142905
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:7; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
EXCRETION
EXHALATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MEASURING METHODS
NUCLEI
ORGANS
PERFUSED ORGANS
PHYSIOLOGY
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
TRACER TECHNIQUES
XENON 133
XENON ISOTOPES